Dual addressing of thymidine synthesis pathways for effective targeting of proliferating melanoma
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چکیده
منابع مشابه
Dual addressing of thymidine synthesis pathways for effective targeting of proliferating melanoma
Here, we examined the potential of blocking the thymidine de novo synthesis pathways for sensitizing melanoma cells to the nucleoside salvage pathway targeting endogenous DNA irradiation. Expression of key nucleotide synthesis and proliferation enzymes thymidylate synthase (TS) and thymidine kinase 1 (TK1) was evaluated in differentiated (MITFhigh [microphthalmia-associated transcription factor...
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ژورنال
عنوان ژورنال: Cancer Medicine
سال: 2017
ISSN: 2045-7634
DOI: 10.1002/cam4.1113